Supplier & Manufacturer of Hydroquinone USP in India

Hydroquinone

Hydroquinone decreases the formation of melanin in the skin. Melanin is the pigment in skin that gives it a brown color.

Hydroquinone topical (for the skin) is used to lighten areas of darkened skin such as freckles, age spots, melasma(sun damage), or chloasma (darkened skin caused by hormonal changes).

Hydroquinone topical may also be used for purposes not listed in this medication guide.

Certificate of Analysis

Description
White to almost white, crystalline powder.
Result
Complies
Identification by IR
Positive
Result
Positive
Identification by Na
Negative
Result
Negative
Solubility
Practically insoluble in Water, Freely soluble in Ethanol
Result
Complies
Optical Rotation
-7° to -12° c
Result
-9.4° C
Water
1.4 to 2.0 %
Result
1.8%
Sulphated Ash
NMT 0.2%
Result
0.01%
Residue Solvents
99.0% to 100.5%
Result
99.63%

Note: We are leading channel partner of much API manufacturer, supplier & exporters and Pharmaceutical raw material in Colombo, Chili, Ecuador and Globally.

MATERIAL SAFETY DATA SHEET

Section 1 – Chemical Product
Product Identifier
Hydroquinone
MSDS Prepared By
R&D Department
Section 2 – Composition / Information Of Ingredients
Product Name
Hydroquinone
Synonymous Name
1,4-benzenedio
CAS Number
123-31-9
Section 3 – HAZARDOUS IDENTIFICATION
Health Hazard
Acute toxicity (Oral)
Category 4
Serious eye damage
Category 1
Skin Sensitizer
Category 1
Germ Cell Mutagenicity
Category 2
Specific Target Organ Toxicity – Single Exposure (Dermal)
Category 2
OSHO Specified Hazards
Combustible Dust
If converted to small particles during further processing, handling or by other means may form combustible dust concentrations in air.
Signal Words
Danger!
Hazards Statements
H302
Harmful if swallowed.
H318
Causes serious eye damage.
H317
May cause an allergic skin reaction.
H341
Suspected of causing genetic defects.
H371
May cause damage to organs. If converted to small particles during further processing, handling or by other means may form combustible dust concentrations in air.
Precautionary Statements
Preventions
P201
Obtain special instructions before use.
P202
Do not handle until all safety precautions have been read and understood.
P281
Use personal protective equipment as required
P264
Wash hands thoroughly after handling.
P270
Do not eat, drink or smoke when using this product.
P260
Do not breathe dust / fume / gas / mist / vapors / spray.
P280
Wear protective gloves / Protective clothing / Eye protection / Face protection
P272
Contaminated work clothing should not be allowed out of the workplace.
Response
P309+P311
IF exposed or if you feel unwell: Call a POISON CENTER or doctor / physician.
P301+P312
IF SWALLOWED: Call a POISON CENTER or doctor / physician if you feel unwell.
P330
Rinse mouth
P302+P352
IF ON SKIN: Wash with plenty of soap and water.
P333+P313
If skin irritation or rash occurs: Get medical advice / attention.
P363
Wash contaminated clothing before reuse.
P305+P351+P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310
Immediately
Storage
P405
Store locked up.
Disposal
P501
Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Section 4 – FIRST AID
Skin Contact
Immediately remove contaminated clothing and shoes and wash skin with soap and plenty of water. If skin irritation or an allergic skin reaction develops, get medical attention. Wash contaminated clothing before reuse. Destroy or thoroughly clean contaminated shoes.
Eye Contact
Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contact lenses. Get medical attention. In case of irritation from airborne exposure, move to fresh air. Get medical attention if symptoms persist.
Inhalation
Move to fresh air. Treat symptomatically. Get medical attention if symptoms persist.
Ingestion
Call a physician or poison control centre immediately. Only induce vomiting at the instruction of medical personnel. Never give anything by mouth to an unconscious person.
Important Information
Call a physician or poison control centre immediately. Only induce vomiting at the instruction of medical personnel. Never give anything by mouth to an unconscious person.
Hazards
N/A
Treatment
Treat symptomatically
Section 5 – FIRE FIGHTING MEASURES
General Fire Hazards
Material can accumulate static charges which may cause an electrical spark (ignition source). Use proper bonding and/or grounding procedures.
Extinguishing Media
Suitable Extinguishing Media
N/A
Unsuitable Extinguishing Media
Water spray. Dry chemical. Carbon Dioxide. Water spray. Carbon Dioxide. Dry chemical.
Special hazards arising from the substance or mixture
Powdered material may form explosive dust-air mixtures
Advice for Fire-Fighters
Special Fire-Fighting Procedures
Minimize dust generation and accumulation.
Special protective equipment for fire-fighters
Self-contained breathing apparatus and full protective clothing must be worn in case of fire.
Section 6 – ACCIDENT RELEASE MEASURES
Personal Precautions
Wear appropriate personal protective equipment.
Environmental Precautions
Do not release into the environment.
Methods and material for containment and cleaning up
Sweep up and place in a clearly labeled container for chemical waste. Large Spillages: Flush spill area with water spray. Prevent runoff from entering drains, sewers, or streams. Dike for later disposal.
Notification Procedures
In the event of a spill or accidental release, notify relevant authorities in accordance with all applicable regulations.
Section 7 – HANDLING AND STORAGE
Handling
Avoid breathing dust. Avoid contact with eyes, skin, and clothing. Do not taste or swallow. Use only with adequate ventilation. Wash thoroughly after handling.
Storage
Keep container closed. Keep away from food, drink and animal feeding stuffs.
Specific end user(s)
Inhibitor Chemical Intermediate Photographic processing chemical.
Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION
Appropriate Engineering Controls
Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level.
Personal Protective Equipment
General information
Eye bath. Washing facilities. Safety shower.
Eye / Face Protection
Chemical goggles and face shield are recommended. Wear a full-face respirator, if needed.
Skin / Hand Protection
Wear chemical-resistant gloves, footwear, and protective clothing appropriate for the risk of exposure. Contact health and safety professional or manufacturer for specific information. Wash hands after contact.
Respiratory Protection
If engineering controls do not maintain airborne concentrations below recommended exposure limits (where applicable) or to an acceptable level (in countries where exposure limits have not been established), an approved respirator must be worn. In the United States of America, if respirators are used, a program should be instituted to assure compliance with OSHA Standard 63 FR 1152, January 8, 1998. Respirator type: Air- purifying respirator with an appropriate, government approved (where applicable), air-purifying filter, cartridge or canister. Contact health and safety professional or manufacturer for specific information.
Hygiene Measures
Observe good industrial hygiene practices.
Environmental Controls
N/A
Section 9 – PHYSICAL AND CHEMICAL PROPERITIES
Physical State
Solid
Form
Solid (Crystal)
Odor
Odorless
Odor Threshold
N/A
Melting Point
172.3 °C
Boiling Point
287 °C
Flash Point
165 °C (closed cup)
Evaporation Rate
N/A
Flammability (Solid, Gas)
N/A
Flammability Limit – Upper (%)
N/A
Flammability Limit – Lower (%)
N/A
Vapor Pressure
0.000032 hPa (25 °C)
Vapor density (air=1)
3.8
Specific Gravity
1.33 (15 °C)
Solubility in Water
72 g/l (25 °C)
Solubility (other)
N/A
Partition coefficient (n-octanol/water)
log Pow: 0.59
Autoignition Temperature
515 °C
Decomposition Temperature
Thermal stability not tested. Low stability hazard expected at normal operating temperatures.
Dynamic Viscosity
N/A
Kinematic Viscosity
N/A
Explosive Properties
N/A
Oxidizing Properties
N/A
Section 10 – STABILITY AND REACTIVITY
Reactivity
No
Chemical Stability
Stable
Possibility of Hazardous Reactions
N/A
Conditions to Avoid
Heat, sparks, flames, Light.
Incompatible Materials
Strong oxidizing agents. Strong alkalis.
Hazardous Decomposition Products
Carbon Dioxide. Carbon Monoxide.
Section 11 – TOXICOLOGICAL INFORMATION
Information on likely routes of exposure
Inhalation
No
Ingestion
Harmful if swallowed.
Skin Contact
May cause an allergic skin reaction. May cause skin depigmentation.
Eye Contact
Causes serious eye damage.
Incompatible Materials
Strong oxidizing agents. Strong alkalis.
Specified Substance(s)
Hydroquinone
Oral LD-50: (Rat): > 375 mg/kg
Dermal
Product
N/A
Specified Substance(s)
Hydroquinone
Dermal LD-50: (Rabbit): > 2,000 mg/kg
Inhalation
Product
N/A
Repeated Dose Toxicity
Product
N/A
Specified Substance(s)
Hydroquinone
NOAEL (Rat, Oral Study. 90 d) : 20 ng/kg – NOAEL (Rat, Dermal Study. 90 d) : 73.9 ng/kg (highest dose tested)
Skin Corrosion/Irritation
Product
N/A
Specified Substance(s)
Hydroquinone
N/A
Serious Eye Damage / Eye Irritation
Product
N/A
Specified Substance(s)
Hydroquinone
(Human): corneal opacity
Respiratory or Skin Sensitization
Product
N/A
Specified Substance(s)
Hydroquinone
Skin Sensitization: (Mouse) : Sensitizing / Skin Sensitization: (Guinea Pig) : Not a skin Sensitizer.
Carcinogenicity
Product
N/A
Toxicity to Reproduction
Product
N/A
Developmental Toxicity
Product
N/A
Germ Cell Mutagenicity
Product
N/A
Specified Substance(s)
Hydroquinone
Mutagenicity – Bacterial: negative / Chromosomal aberration: negative / Chromosomal aberration: positive / Chromosomal aberration: negative / Mutagenicity – Mammalian: positive
In Vivo
Product
N/A
Specified Substance(s)
Hydroquinone
Chromosomal aberration intraperitoneal injection (Mouse): Positive / Chromosomal aberration oral Gavage (Rat): Negative
Specific Target Organ Toxicity
Product
N/A
Single Exposure Specific Target
Product
N/A
Organ Toxicity – Repeated Exposure
Product
N/A
Aspiration Hazard
Product
N/A
Section 12 – ECOLOGICAL INFORMATION
Ecotoxicity
Acute hazards to the aquatic Environment
Fish
Product
N/A
Specified Substance(s)
Hydroquinone
LC-50 (Fish, 96 h): 0.638 mg/l
Aquatic Invertebrates
Product
N/A
Specified Substance(s)
Hydroquinone
EC-50 (daphnid, 48 h): 0.134 mg/l
Chronic hazards to the aquatic Environment
Fish
Aquatic Invertebrates
Product
N/A
Specified Substance(s)
Hydroquinone
NOEC: (daphnid, 21 d): 0.0057 mg/l
Toxicity to Aquatic Plants
Product
N/A
Aquatic Invertebrates
Product
N/A
Specified Substance(s)
Hydroquinone
EC-50 (Alga, 72 n) 0.33 mg/l – NOEC (Alga, 72 n) 0.019 mg/l
Persistence and Degradability Biodegradation
Product
N/A
Specified Substance(s)
Hydroquinone
70 % (14 d, Ready Biodegradability: Modified MITI Test (I)) Readily biodegradable
BOD/COD Ratio
Product
N/A
Bioaccumulative Potential Bioconcentration Factor (BCF)
Product
N/A
Partition Coefficient n-octanol / Water (log Kow)
Product
Log Kow: 0.59 20 °C
Mobility in Soil
N/A
Known or Oredicted Distribution to Environmental Compartments
Hydroquinone
Log Koc: 0.97 – 1.7 (QSAR model)
Other Adverse Effect
N/A
Section 13 – DISPOSAL CONSIDERATION
General Information
N/A
Disposal Methods
Dispose of waste and residues in accordance with local authority requirements. Incinerate. Since emptied containers retain product residue, follow label warnings even after container is emptied.
Section 14 – TRANSPORT INFORMATION
Important Note
Shipping descriptions may vary based on mode of transport, quantities, package size, and/or origin and destination. Consult your company’s Hazardous Materials/Dangerous Goods expert for information specific to your situation.
DOT
Class 9, Packing Group III when material is shipped in quantities in one package at or above the Reportable Quantity and when no other hazard class applies; otherwise, not regulated.
Possible Shipping Description
UN 3077 Environmentally hazardous substances, solid, n.o.s. (hydroquinone)
IMDG
Marine pollutant.: (hydroquinone)
Possible Shipping Description
UN 3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (hydroquinone)
IATA Possible Shipping Description
UN 3077 Environmentally hazardous substance, solid, n.o.s. (hydroquinone)
Section 15 – REGULATORY INFORMATION
OSHA
Hazardous
TSCA (US Toxic Substances Control Act)
This product is listed on the TSCA inventory. Any impurities present in this product are exempt from listing.
DSL (Canadian Domestic Substances List) and CEPA (Canadian Environmental Protection Act)
This product is listed on the DSL or otherwise complies with CEPA new substance notification requirements.
AICS / NICNAS (Australian Inventory of Chemical Substances and National Industrial Chemicals Notification and Assessment Scheme)
This product is listed on AICS or otherwise complies with NICNAS.
MITI (Japanese Handbook of Existing and New Chemical Substances)
This product is listed in the Handbook or has been approved in Japan by new substance notification.
ECL (Korean Toxic Substances Control Act)
This product is listed on the Korean inventory or otherwise complies with the Korean Toxic Substances Control Act.
HMIS Hazard Ratings
Health
2*
Flammability
1
Chemical Reactivity
0
Section 16 – OTHER INFORMATION
Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.
Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.