Diacerein is a medicine that is used to relieve pain, stiffness and swelling of joints associated with osteoarthritis.
Osteoarthritis is a joint disorder caused when the protective cartilage which acts as a cushion between two ends of bones wears down, leading to joint tenderness and pain with movement.
It works by forming a soft connective tissue around the joints (cartilage), thus it relieves pain and swelling at the joints.
Material Safety Data Sheet
SECTION 1 – CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
MSDS Identification Name : Diacerein
Supplier : ATILUS PHARMA PVT. LTD.
SECTION 2 – COMPOSITION, INFORMATION ON INGREDIENTS
CAS No. : 13739-02-1
Chemical Name : 1,8-Diacetoxy-3-carboxyanthraquinone
Synonyms : 1,8-Diacetoxy-3-carboxyanthraquinone
Formula : C19H12O8
Molecular weight : 368,29 g/mol
SECTION 3 – HAZARDS IDENTIFICATION
3.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Specific target organ toxicity – single exposure (Category 3), Respiratory system, H335
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Hazard statement(s)
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s)
P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard
Statements
None
Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
Ecological information:
The substance/mixture does not contain components considered to have endocrine
disrupting properties according to REACH Article 57(f) or Commission Delegated regulation
(EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Toxicological information:
The substance/mixture does not contain components considered to have endocrine
disrupting properties according to REACH Article 57(f) or Commission Delegated regulation
(EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
SECTION 4 – FIRST AID MEASURES
4.1 Description of first-aid measures
General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult
a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
SECTION 5 – FIRE FIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
SECTION 6 – ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or
gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in
suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
SECTION 7 – HANDLING AND STORAGE
7.1 Precautions for safe handling
Advice on safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Advice on protection against fire and explosion
Provide appropriate exhaust ventilation at places where dust is formed.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before
breaks and at the end of workday.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Store in cool place.
Storage class
Storage class (TRGS 510): 11: Combustible Solids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8 – EXPOSURE CONTROLS, PERSONAL PROTECTION
8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye
protection tested and approved under appropriate government standards such as
NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove’s outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
Body Protection
Impervious clothing, The type of protective equipment must be selected according
to the concentration and amount of the dangerous substance at the specific
workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle
respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU
EN 143) respirator cartridges. Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.
SECTION 9 – PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
- a) Appearance Form : Solid
- b) Odor : Not applicable
- c) Odor : Not applicable
- d) pH : No data available
- e) Melting point/freezing point Melting point/range: No data available
- f) Autoignition :No data available
temperature
- g) Decomposition temperature :No data available
- h) Viscosity Viscosity, kinematic : No data available
Viscosity, dynamic : No data available
- i) Explosive properties : No data available
- j) Oxidizing properties :No data available
9.2 Other safety information
No data available
SECTION 10 – STABILITY AND REACTIVITY
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
In the event of fire: see section 5
SECTION 11 – TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Remarks: No data available
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity – single exposure
Inhalation – May cause respiratory irritation.
Specific target organ toxicity – repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
SECTION 12 – ECOLOGICAL INFORMATION
12.1 Toxicity
No data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
12.7 Other adverse effects
No data available
SECTION 13 – DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or
mix the material with a combustible solvent and burn in a chemical incinerator equipped
with an afterburner and scrubber. Waste material must be disposed of in accordance with
the Directive on waste 2008/98/EC as well as other national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers
like the product itself.
Contaminated packaging
Dispose of as unused product.
SECTION 14 – TRANSPORT INFORMATION
14.1 UN number
ADR/RID: – IMDG: – IATA: –
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: – IMDG: – IATA: –
14.4 Packaging group
ADR/RID: – IMDG: – IATA: –
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available
Further information
Not classified as dangerous in the meaning of transport regulations.
SECTION 15 – REGULATORY INFORMATION
15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
SECTION 16 – ADDITIONAL INFORMATION
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages.
