Permethrin is an anti-parasite medication.
Permethrin topical (for the skin) is used to treat head lice and scabies.
Permethrin topical may also be used for other purposes not listed in this medication guide.
Certificate of Analysis
- Description
Yellow coloured liquid which solidity on standing at lower temperature.
Result
Yellow brownish colour liquid which may solidity on standing at lower temperature.
- Solubility
Soluble in Alcohol(96% w/v), Acetone, ether & hydrocarbons (Toluene)
Result
Soluble in Alcohol(96% w/v), Acetone, ether & hydrocarbons (Toluene)
- Identification By IR
IR spectrum exhibits maxima which are only at same wave number as those in spectrum permethrin standard.
Result
The IR spectrum of the sample is concordant with the spectrum obtained with permethrin standard.
- Identification By HPLC
Retention time of permethrin test sample matches with retention time of permethrin standard in the assay test.
Result
Retention time of permethrin test sample matches with retention time of permethrin standard in the assay test.
- Loss on Drying
0.37 %
Result
NMT 2.0 %
- Sulphated ash
0.10 %
Result
NMT 0.2 %
- Assay by HPLC(on dried basis)
99.87 %
Result
NMT 95.0%
- Cis Isomer
25.68 %
Result
23.0 % to 27.0 %
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Material Safety Data Sheet
Section 1 – Chemical Product
Product Identifier
Permethrin
MSDS Prepared By
R&D Department
Section 2 – Composition / Information Of Ingredients
Product Name
Permethrin
Synonym
PERMETHRIN (FMC 33297): 3-phenoxybenzyl (1RS,3RS;1RS,3SR)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate or 3-phenoxybenzyl (1RS)-cis-trans-3-(2,2-dichlorovinyl)-2,2- dimethylcyclopropanecarboxylate (IUPAC name); (3phenoxyphenyl) methyl 3-(2,2-dichloroethenyl) -2,2dimethylcyclopropanecarboxylate
Molecular Weight (%)
36.8%
CAS No
52645-53-1
Section 3 – HAZARDOUS IDENTIFICATION
Classification
OSHA Regulatory Status
This material should consider hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200)
Acute toxicity – Oral
Category 4
Acute toxicity – Inhalation (Dusts/Mists)
Category 4
Skin sensitization
Category 1B
Specific target organ toxicity (single exposure)
Category 2
Specific target organ toxicity (repeated exposure)
Category 2
Aspiration toxicity
Category 1
Emergency Overview Hazard Statements
H302
Harmful if swallowed.
H304
May be fatal if swallowed & enters airways.
H317
May cause an allergic skin reaction.
H332
Harmful if inhaled.
H371
May cause damage to organs.
H373
May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements – Prevention
P264
Wash face, hands and any exposed skin thoroughly after handling.
P270
Do not eat, drink or smoke when using this product.
P272
Contaminated work clothing should not be allowed out of the workplace.
P280
Wear protective gloves
P260
Do not breathe Dust / Fume / Gas / Mist. / Vapors / Spray.
Precautionary Statements – Response
P308 + P311
If exposed or concerned: Call a POISON CENTER or doctor.
P302 + P352
IF ON SKIN: Wash with plenty of water and soap.
P333 + P313
If skin irritation or rash occurs: Get medical advice/attention.
P363
Wash contaminated clothing before reuse.
P304 + P340
IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P312
Call a POISON CENTER or doctor if you feel unwell.
P301 + P310
IF SWALLOWED: Immediately call a POISON CENTER or doctor .
P331
Do NOT induce vomiting.
P330
Rinse mouth
Precautionary Statements – Storage
P405
Store locked up.
Precautionary Statements – Disposal
P501
Dispose of contents/container to an approved waste disposal plant.
Hazards not otherwise classified (HNOC)
No hazards not otherwise classified were identified.
Other Information
Very toxic to aquatic life with long lasting effects. Causes mild skin irritation. May be harmful in contact with skin.
Section 4 – FIRST AID
Eye Contact
Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for further treatment advice.
Skin Contact
Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for further treatment advice.
Inhalation
Move to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably mouth-to-mouth if possible. Call a poison control center or doctor for further treatment advice.
Ingestion
Immediately call a poison control center or doctor. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give any liquid to the person. Do not give anything by mouth to an unconscious person.
Most important symptoms and effects, both acute and delayed
Central nervous system effects.
Indication of immediate medical attention and special treatment needed, if necessary
This product is a pyrethroid. If large amounts have been ingested, the stomach and intestines should be evacuated. Treatment is symptomatic and supportive. Digestible fats, oils, or alcohol may increase absorption and so should be avoided. Contains petroleum distillate. Vomiting may cause aspiration pneumonia.
Section 5 – FIRE FIGHTING MEASURES
Suitable Extinguishing Media
Foam, carbon dioxide (CO2). Dry chemical. Water spray or fog.
Specific Hazards Arising from the Chemical
Combustible Liquid
Explosion Data
Sensitivity to Mechanical Impact
N/A
Sensitivity to Static Discharge
N/A
Protective equipment and precautions for firefighters
As in any fire, wear self-contained breathing apparatus and full protective gear. Isolate fire area. Evaluate upwind.
Section 6 – ACCIDENT RELEASE MEASURES
Personal Precautions
Isolate & post spill area. Remove all sources of ignition. Wear suitable protective clothing, gloves & eye/face protection. For personal protection see Section 8.
Environmental Precautions
Keep people & animals away from & upwind of spill/leak. Keep material out of lakes, streams, ponds & sewer drains. Keep out of waterways.
Methods of Containment
Dike to prevent runoff. Absorb with earth, sand or other non-combustible material & transfer to containers for later disposal.
Methods for Cleaning Up
Clean & neutralize spill area, tools & equipment by washing with water & soap. Absorb rinse & add to the collected waste. Waste must be classified & labeled prior to recycling or disposal. Dispose of waste as indicated in Section 13.
Section 7 – HANDLING AND STORAGE
Handling
Do not contaminate other pesticides, fertilizers, water, food, or feed by storage or disposal.
Storage
Keep in a dry, cool and well-ventilated place. Keep away from open flames, hot surfaces and sources of ignition. Keep out of reach of children and animals. Keep/store only in original container.
Incompatible Products
Not known
Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Measures
Apply technical measures to comply with the occupational exposure limits. Ensure adequate ventilation, especially in confined areas. When working in confined spaces (tanks, containers, etc.), ensure that there is a supply of air suitable for breathing and wear the recommended equipment.
Personal Protective Equipment
Eye/Face Protection
If there is a potential for exposure to particles which could cause eye discomfort, wear chemical goggles.
Skin & Body Protection
Wear long-sleeved shirt, long pants, socks, and shoes.
Hand Protection
Protective gloves
Respiratory Protection
If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Respiratory protection must be provided in accordance with current local regulations.
Hygiene Measures
Clean water should be available for washing in case of eye or skin contamination. Wash skin prior to eating, drinking, chewing gum or using tobacco. Shower or bathe at the end of working. Remove and wash contaminated clothing before re-use. Launder work clothing separately from regular household laundry.
General information
If the product is used in mixtures, it is recommended that you contact the appropriate protective equipment suppliers.
Section 9 – PHYSICAL AND CHEMICAL PROPERITIES
Appearance
Amber Liquid
Physical State
Liquid
Color
Amber
Odor
Faint Hydrocarbon
Odor Threshold
N/A
Melting / Freezing Point
N/A
Boiling Point
N/A
Flash Point
82.2°C / 179.96°F Tag Closed Cup
Evaporation Rate
N/A
Flammability (Solid, Gas)
N/A
Lower Flammability Limit
N/A
Upper Flammability Limit
N/A
Vapor Pressure
N/A
Vapor Density
N/A
Density
8.61 lb/gal
Specific Gravity
1.0333 @ 20°C
Water Solubility
Emulsifies
Solubility in other Solvents
N/A
Partition Coef.
N/A
Autoignition Temperature
N/A
Decomposition Temperature
N/A
Viscosity, kinematic
N/A
Viscosity, dynamic
N/A
Explosive Properties
N/A
Oxidizing Properties
N/A
Bulk Density
N/A
Section 10 – STABILITY AND REACTIVITY
Reactivity
None under normal use conditions.
Chemical Stability
Stable under recommended storage conditions.
Possibility of Hazardous Reactions
None under normal processing.
Hazardous polymerization
Hazardous polymerization does not occur.
Conditions to avoid
Excessive heat, Extreme risk of explosion by shock, friction, fire or other sources of ignition
Incompatible materials
None known.
Hazardous Decomposition Products
Chlorine, hydrogen chloride, Carbon oxides (COx), Aldehydes.
Section 11 – TOXICOLOGICAL INFORMATION
Product Information
LD50 Oral
998 mg/kg (rat)
LD50 Dermal
Less than 2000 mg/kg (rabbit)
LD50 Inhalation
Less than 4.3 mg/L 4 hr (rat)
Skin Corrosion / Irritation
Moderately irritating.
Serious Eye Damage / Irritation
Mildly irritating
Sensitization
Sensitizer
Information on Toxicological Effects
Symptoms
Large toxic doses of the formulated product, administered by ingestion to animals, produced central nervous system effects with symptoms that include hypersensitivity to touch and sound, tremors, and clinic convulsions. Overexposure via inhalation produced symptoms such as squinting eyes, irregular and rattling breathing, and ataxia.
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Chronic Toxicity
Effects are expected to be similar to those that are seen with acute toxicity.
Mutagenicity
Not genotoxic in laboratory studies.
Carcinogenicity
Evidence of tumors in mice but is not considered relevant to humans.
Neurological Effects
Clinical signs of neurotoxicity include altered motor activity and FOB effects, with no signs of histopathology.
Reproductive Toxicity
No toxicity to reproduction in animal studies.
Developmental Toxicity
Not teratogenic in animal studies.
STOT Single Exposure
May cause damage to organs. See listed target organs below.
STOT – repeated exposure
May cause damage to organs through prolonged or repeated exposure. See listed target organs below.
Target organ effects
Central Nervous System (CNS).
Neurological effects
Clinical signs of neurotoxicity include altered motor activity and FOB effects, with no signs of histopathology.
Section 12 – ECOLOGICAL INFORMATION
Persistence & Degradability
Moderately persistent. Does not readily hydrolyze. Not readily biodegradable.
Bioaccumulation
The substance has a potential for bioconcentration.
Mobility
Immobile; Not expected to reach groundwater.
Section 13 – DISPOSAL CONSIDERATION
Waste disposal methods
Pesticide wastes are toxic. Improper disposal of excess pesticide, spray mixture, or rinsate is prohibited. If these wastes cannot be disposed of by use according to label instructions, contact appropriate disposal authorities for guidance. Proper personal protective equipment, as described in Sections 7 and 8, must be worn while handling materials for waste disposal.
Contaminated Packaging
Containers must be disposed of in accordance with local, state and federal regulations. Refer to the product label for container disposal instructions.
Section 14 – TRANSPORT INFORMATION
DOT
DOT
The classification below pertains to the shipment in bulk and non-bulk packaging.
UN/ID No
NA1993
Proper Shipping Name
Combustible liquid, n.o.s
Hazard Class
Combustible
Packing Group
III
Description
NA1993, Combustible liquid, n.o.s. (Aromatic hydrocarbons), III
TDG
TDG
Classification below is only applicable when shipped by vessel and is not applicable when shipped by road or rail only.
UN/ID No
UN3082
Proper Shipping Name
Environmentally hazardous substance, liquid, n.o.s.
Hazard Class
9
Packing Group
III
Marine Pollutant
Permethrin
Description
UN3082, Environmentally hazardous substance, liquid, n.o.s. (permethrin), 9, PGIII, Marine Pollutant
ICAO/IATA
UN/ID No
UN3082
Proper Shipping Name
Environmentally hazardous substance, liquid, n.o.s.
Hazard Class
9
Packing Group
III
Description
UN3082, Environmentally hazardous substance, liquid, n.o.s. (permethrin), 9, PGIII, Marine Pollutant
IMDG/IMO
UN/ID No
UN3082
Proper Shipping Name
Environmentally hazardous substance, liquid, n.o.s.
Hazard Class
9
Packing Group
III
Marine Pollutant
Permethrin
Description
UN3082, Environmentally hazardous substance, liquid, n.o.s. (permethrin), 9, PGIII, Marine Pollutant
Section 15 – REGULATORY INFORMATION
U.S. Federal Regulations
SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product contains a chemical or chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
SARA 311/312 Hazard Categories
Acute Health Hazard
Yes
Chronic Health Hazard
Yes
Fire Hazard
Yes
Sudden release of pressure Hazard
No
Reactive Hazard
No
Clean Water Act
This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42).
CERCLA
This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302).
FIFRA Information
This chemical is a pesticide product registered by the Environmental Protection Agency and is subject to certain labeling requirements under federal pesticide law. These requirements differ from the classification criteria and hazard information required for safety data sheets, and for workplace labels of non-pesticide chemicals. Following is the hazard information as required on the pesticide label.
Caution
Harmful if swallowed. Harmful if absorbed through the skin. Prolonged or frequent skin contact may cause allergic reactions in some individuals. This product is extremely toxic to fish and aquatic invertebrates.
US State Regulations
California Proposition 65
This product does not contain any Proposition 65 chemicals.
Mexico – Grade
Moderate risk
Grade 2
WHMIS Statement
This product has been classified in accordance with the Hazardous Products Regulations (HPR) and the SDS contains all the information required by the HPR.
WHMIS Hazard Class
D2B
Toxic materials
National Fire Protection Association (NFPA)
Health Hazard
2
Flammability
2
Instability
0
Special Hazard
N/A
Health Management Information System (HMIS)
Health Hazard
2
Flammability
2
Physical Hazard
0
Personal Protection
X
Section 16 – OTHER INFORMATION
Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.
Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.
