Supplier & Manufacturer of L Arginine Base in India

L Arginine Base

L-Arginine is an amino acid naturally found in red meat, poultry, fish, and dairy. It is necessary for making proteins and is commonly used for circulation.

L-Arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body. It can be made in a lab and used in supplements.

Certificate of Analysis

Appearance
White or almost white, crystalline powder or colorless crystals, hygroscopic.
Solubility
Freely soluble in water, very slightly soluble in ethanol. (96 per cent).
Identification By IR
To match with the reference IR spectrum
Identification By TLC
The principal spot in the chromatogram obtained with the test solution is similar in position, color and size to the principal spot in the chromatogram obtained with the reference solution.
Chloride
NMT 0.05 %
Sulphate
NMT 0.03 %
Iron
NMT 30 ppm
Residue on Ignition
NMT 0.3 %
Specific Rotation
+26.3° ~ +27.7°
Heavy Metal
NMT 10 ppm
Loss on drying
NMT 0.5 %
Organics Impurities by TLC
Individual Impurities
NMT 0.5 %
Total Impurities
NMT 2.0 %
Assay by Titration
NLT 98.5 & NMT 101.5 %

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Material Safety Data Sheet

- Section 1 – Chemical Product
  Product Identifier
  L-Arginine Base
  MSDS Prepared By
  R&D Department
- Section 2 – Composition / Information Of Ingredients
  Product Name
  L-Arginine Base
  Chemical Name
  (S)-2-Amino-5-guanidinopentanoic acid
  EINECS #
  200-811-1
  Synonym
  (S)-2-Amino-5-guanidinopentanoic acid
  Molecular Formula
  C6H14N4O2
  Molecular Weight
  174.2 g/mol
  CAS Number
  74-79-3
- Section 3 – HAZARDOUS IDENTIFICATION
  Classification of the substance or mixture
  .
  Classification according to Regulation (EC) No 1272/2008
  Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
  Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.
  Other Hazards
  This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
- Section 4 – FIRST AID
  After inhalation
  Fresh air
  Skin Contact
  In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
  Eye Contact
  RRinse out with plenty of water. Remove contact lenses.
  Swallowed
  Make victim drink water (two glasses at most). Consult doctor if feeling unwell.
  Most important symptoms and effects, both acute and delayed
  The most important known symptoms and effects are described in the labelling (see secti2.2) and/or in section 11
  Indication of any immediate medical attention and special treatment needed
  N/A
- Section 5 – FIRE FIGHTING MEASURES
  Extinguishing media
  Suitable extinguishing media
  Water Foam Carbon dioxide (CO2) Dry powder
  Unsuitable extinguishing media
  For this substance/mixture no limitations of extinguishing agents are given.
  Special hazards arising from the substance or mixture
  Carbon oxides Nitrogen oxides (NOx) Combustible. Fire may cause evolution of: nitrogen oxides Development of hazardous combustion gases or vapours possible in the event of fire.
  Advice for firefighters
  In the event of fire, wear self-contained breathing apparatus.
  Further information
  Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
- Section 6 – ACCIDENT RELEASE MEASURES
  Personal precautions, protective equipment and emergency procedures
  Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert.
  Environmental precautions
  Do not let product enter drains.
  Methods and materials for containment and cleaning up
  Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
  Reference to other sections
  For disposal see section 13.
- Section 7 – HANDLING AND STORAGE
  Precautions for safe handling
  For precautions see section 2.2.
  Storage
  Tightly closed. Dry. Store at +5°C to +30°C.
  Specific end use(s)
  Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
- Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION
  Control parameters
  Ingredients with workplace control parameters.
  Personal protective equipment
  Eye/face protection
  SUse equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses.
  Skin protection
  This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Respiratory protection

required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains.

Section 9 – PHYSICAL AND CHEMICAL PROPERITIES
Physical state and appearance
Solid.
Color
White.
Odor
Weak
Odor Threshold
N/A
pH
ca.11,4 at 100 g/l at 20 °C
Melting Point/freezing Point
Melting point/range: 223 – 224 °C at ca.1.013 hPa
Initial boiling point and boiling range
N/A
Flash Point
N/A
Evaporation rate
Flammability (solid, gas) The product is not flammable
Flammability (solids)
Upper/lower flammability or explosive limits
N/A
Vapor Pressure
< 0,1 hPa at 25 °C
Vapor Density
N/A
Relative density
1,1 g/cm
Water solubility
182 g/l at 25 °C – completely soluble
Viscosity kinematic
N/A
Viscosity dynamic
N/A
Explosive Properties
N/A
Oxidizing Properties
N/A
Bulk density
ca.640 kg/m³
Dissociation constant
2,17 at 20 °C
Section 10 – STABILITY AND REACTIVITY
Reactivity
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature).
Possibility of hazardous reactions
Violent reactions possible with
Strong oxidizing agents
Conditions to avoid
N/A
Incompatible materials
N/A
Hazardous decomposition products
In the event of fire: see section 5
Section 11 – TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
LD50 Oral – Rat – male and female
> 5.110 mg/kg Remarks: (ECHA)
Skin corrosion/irritation
Skin
Rabbit
Result
No skin irritation – 4 h
Serious eye damage/eye irritation
Eyes
Rabbit
Result
No eye irritation – 1 h
Respiratory or skin sensitization
N/A
Germ cell mutagenicity
Mutagenicity (mammal cell test)
chromosome aberration. Human lymphocytes
Result
Negative
Carcinogenicity
IARC
No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
N/A
Specific target organ toxicity – single exposure
N/A
Specific target organ toxicity – repeated exposure
N/A
Aspiration hazard
N/A
Section 12 – ECOLOGICAL INFORMATION
Toxicity
Toxicity to fish semi-static test LC50 – Danio rerio (zebra fish) – 2.800 mg/l – 96 h (OECD Test Guideline 203)
Persistence and degradability
Biodegradability aerobic
Exposure time 28 d
Bioaccumulative potential
N/A
Mobility in soil
N/A
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
N/A
Section 13 – DISPOSAL CONSIDERATION
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and nonrecyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.;
Contaminated packaging
Dispose of as unused product.
Section 14 – TRANSPORT INFORMATION
UN number
ADR/RID
IMDG – IATA
UN proper shipping name
ADR/RID
Not dangerous goods
IMDG
Not dangerous goods
IATA
Not dangerous goods
Transport hazard class(es)
ADR/RID
IMDG – IATA
Packaging group
ADR/RID
IMDG – IATA
Environmental hazards
ADR/RID
No IMDG Marine pollutant: no IATA: no
Further information
Not classified as dangerous in the meaning of transport regulations.
Section 15 – REGULATORY INFORMATION
Safety, health and environmental regulations/legislation specific for the substance or mixture
Millipore
1.01542 Page 8 of 8. The life science business of Merck operates as MilliporeSigma in the US and Canada. This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.
National legislation
Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. Not applicable
Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
Section 16 – OTHER INFORMATION
Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.
Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.